Percocet vs Vicodin — Which Pain Pill Is Stronger? Which to Buy Online 2025
The Percocet vs Vicodin comparison is one of the most common pain medication questions. Both are combination opioid/acetaminophen tablets — but they differ in active opioid, strength, and use cases. This comprehensive guide breaks down the differences and helps you decide which to buy from LiveStone Pharmacy.
What Is Percocet?
Percocet = Oxycodone + Acetaminophen (APAP). The most common formulation is Percocet 5/325 (oxycodone 5mg + APAP 325mg), though higher strengths exist (7.5/325, 10/325).
- Active opioid: Oxycodone — semi-synthetic; ~1.5× more potent than oral morphine per mg
- Schedule: DEA Schedule II
- Onset: 30–60 minutes
- Duration: 4–6 hours
What Is Vicodin / M366?
Vicodin / M366 = Hydrocodone + Acetaminophen (APAP). The M366 tablet contains Hydrocodone Bitartrate 7.5mg + Acetaminophen 325mg.
- Active opioid: Hydrocodone — semi-synthetic, derived from codeine
- Schedule: DEA Schedule II
- Onset: 30–60 minutes
- Duration: 4–6 hours
Percocet vs Vicodin — Which Is Stronger?
Oxycodone (Percocet) is stronger than Hydrocodone (Vicodin) — approximately 50% more potent per mg. However, M366 contains 7.5mg hydrocodone vs Percocet 5/325's 5mg oxycodone — so in these specific formulations, pain relief is roughly comparable.
| Factor | Percocet 5/325 | M366 (Vicodin 7.5/325) |
|---|---|---|
| Active opioid | Oxycodone 5mg | Hydrocodone 7.5mg |
| APAP per tablet | 325mg | 325mg |
| Opioid potency | Higher per mg (oxycodone) | Lower per mg (hydrocodone) |
| Net analgesic effect | Similar in these doses | Similar in these doses |
| Best for | Moderate-severe acute pain | Moderate pain, dental |
When to Step Up Beyond Percocet and Vicodin
Both Percocet and Vicodin are appropriate for moderate-to-moderately severe pain. For severe chronic pain, consider stepping up to:
- Oxycodone 80mg ER (OxyContin) — 12-hour extended-release; for opioid-tolerant patients
- Morphine 60mg ER — cancer and severe chronic pain
- Dilaudid 8mg — breakthrough severe pain
The APAP (Acetaminophen) Warning — Critical Safety Information
Both Percocet and Vicodin contain acetaminophen (paracetamol). Exceeding 4,000mg APAP/day (3,000mg if elderly or liver-impaired) causes potentially fatal acute liver failure.
- Maximum tablets per day: 8 tablets (of either 325mg APAP formulation)
- Do not combine with Tylenol, cold medicines, or other APAP products
- Avoid alcohol — dramatically increases APAP hepatotoxicity
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References: NCBI — Hydrocodone | MedlinePlus — Oxycodone
